3 edition of Ganglioside structure, function, and biomedical potential found in the catalog.
Ganglioside structure, function, and biomedical potential
|Statement||edited by Robert W. Ledeen ... [et al.].|
|Series||Advances in experimental medicine and biology ;, v. 174|
|Contributions||Ledeen, Robert W., International Society for Neurochemistry. Meeting|
|LC Classifications||QP752.G3 G35 1984|
|The Physical Object|
|Pagination||xii, 649 p. :|
|Number of Pages||649|
|LC Control Number||84008232|
structure of ganglioside GQ1b, one of the most abundant gangliosides in adult human brain (G = ganglio series, Q = 4 sialic acids, 5 − 1 = 4n e u t r a lc a r b o h y d r a t er e s i d u e s,a Author: Thomas Kolter. Title:Ganglioside GM3 and Its Role in Cancer VOLUME: 26 ISSUE: 16 Author(s):Changping Zheng, Marco Terreni, Matthieu Sollogoub and Yongmin Zhang* Affiliation:Sorbonne Universite, CNRS, Institut Parisien de Chimie Moleculaire (UMR ), 4 Place Jussieu, Paris, Drug Sciences Department, University of Pavia, Viale Tarame Pavia, Sorbonne Universite, CNRS, Institut Parisien de Cited by: 4.
ganglioside [gang´gle-o-sīd] a class of galactose-containing cerebrosides found in central nervous system tissues; they are glycolipids of the basic composition ceramide-glucose-galactose-N-acetyl neuraminic acid. The form GM1 accumulates in tissues in generalized gangliosidosis, the form GM2 in Tay-Sachs disease. ganglioside (gang'glē-ō-sīd. ORIGINAL ARTICLE Ganglioside GM3 is essential for the structural integrity and function of cochlear hair cells Misato Yoshikawa1,6,†, Shinji Go1,†, Shun-ichi Suzuki1, Akemi Suzuki2, Yukio Katori3, Thierry Morlet4, Steven M. Gottlieb5, Michihiro Fujiwara6, Katsunori Iwasaki6, Kevin A. Strauss7,8,9 and Jin-ichi Inokuchi1,* 1Division of Glycopathology, Institute of Molecular Biomembranes and.
Only a few mutations in the GM2A gene have been identified in people with GM2-gangliosidosis, AB variant. Some of these mutations change single protein building blocks (amino acids) in the GM2 ganglioside activator. Other mutations delete a small amount of DNA from the GM2A gene. These genetic changes result in an unstable activator protein that is quickly degraded, or they prevent the gene. Ganglioside Structure, Function, and Biomedical Potential Author: Huang Publisher: Huang © ISBN: ; Gangliosides and Modulation of Neuronal Functions Author: Rahmann, Hinrich Publisher: Rahmann, Hinrich © ISBN: ; Gangliosides in Health and Disease, vol. Author: Sakkas Publisher: Sakkas © ISBN.
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This volume contains the proceedings of the symposium on "Ganglioside Structure, Function and Biomedical Potential" which was held at Parksville, Vancouver Island, B.
C., Canada on JulyT. This volume contains the proceedings of the symposium on "Ganglioside Structure, Function and Biomedical Potential" which was held at Parksville, Vancouver Island, B.
C., Canada on JulyThe symposium was organized ao a satellite to the ninth meeting of the Ganglioside structure Society for. This volume contains the proceedings of the symposium on "Ganglioside Structure, Function and Biomedical Potential" which was held at Parksville, Vancouver Island, B.
C., Canada on JulyThe symposium was organized ao a satellite to the ninth meeting of the International Society for Neurochemistry, and biomedical potential book immediately afterward in Author: Robert Ganglioside structure, function, and biomedical potential.
[Robert W Ledeen; International Society for Neurochemistry. Meeting;] -- The first few sessions were devoted to the "conventional" topics of structure, metabolism, and distribution. Although these represent the more established areas of ganglioside research, this meeting. Edition Notes Includes bibliographies and indexes.
"Proceedings of the symposium on ganglioside structure, function, and biomedical potential book biomedical potential, held July, at Parksville, Vancouver Island, British Columbia, Canada satellite to the ninth meeting of the International Society for Neurochemistry held July, at Vancouver, British Columbia."--Verso t.p.
"Fidia Research Pages: Get this from a library. Ganglioside Structure, Function, and Biomedical Potential. [Robert W Ledeen; Robert K Yu; Maurice M Rapport; Kunihiko Suzuki] -- This volume contains the proceedings of the symposium on "Ganglioside Structure, Function and Biomedical Potential" which was held at Parksville, Vancouver Island, B.C., Canada on July A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g.
n-acetylneuraminic acid, NANA) linked on the sugaran acetylated derivative of the carbohydrate sialic acid, makes the head groups of gangliosides anionic at pH 7, which distinguishes them from globosides.
The name ganglioside was first applied by the. Abstract. From the beginning, research on gangliosides has been closely associated with studies of diseases. Although there had been a few articles which may well have described the compounds which we now know as gangliosides, 1,2 discovery of gangliosides is justifiably credited to Klenk, who first discovered them in in the brain of patients with Niemann-Pick disease 3 and then in a Cited by: E.H.
Kolodny, in Encyclopedia of Neuroscience, Molecular Genetics. The hydrolysis of G M2 ganglioside requires the concerted action of three gene products: the α and β subunits of β-hexosaminidase A and the G M2 activator protein. The α and β subunits are encoded by two evolutionarily related genes, HEXA on chromosome 15q23–q24 and HEXB encoded on chromosome.
Purchase Biological Function of Gangliosides, Volume - 1st Edition. Print Book & E-Book. ISBNGangliosides function, for example, as receptors for bacterial toxins, which subsequently activate adenyl cyclase. Different members of each ganglioside class are identified by subscript number (e.g., G M1, G M2, G M3, or G M4), which indicate the specific sequence of oligosaccharide groups attached to ceramide (Fig ).
Figure 2 shows the structures and metabolic pathways of ganglio-series gangliosides. Ganglio-series glycosphingolipids having 0, 1, 2 and 3 sialic acid residue(s) linked to the inner galactose residue are classified into asialo- a- b- and c-series gangliosides, by: This multi-contributor book provides comprehensive coverage of earthquake engineering problems, an overview of traditional methods, and the scientific background on recent developments.
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eye. The GM2 ganglioside is composed of N-Acetyl-D-galactose-beta-1,4-[N-Acetylneuraminidate-alpha-2,3-]-Galactose-beta-1,4-glucose-alpha-ceramide.
A perspective structure of GM2 ganglioside is shown in figure 3 and the corresponding ball-and-stick model is shown in figure 4.
Shown in both of these figures is the stearoyl fatty acid form of. ↑ Ledeen RW & Wu GS () Ganglioside function in calcium homeostasis and signaling. Neurochemical Resea ↑ Rahmann H () Brain Gangliosides and Memory Formation. Behavioural Brain Resea ↑ Wang B & Brand-Miller J.
The role and potential of sialic acid in human nutrition. This volume contains the proceedings of the symposium on "Ganglioside Structure, Function and Biomedical Potential" which was held at Parksville, Vancouver Island, B.
C., Canada on July Language: English ISBN:LCCN: MeSH: Gangliosides* Publication Type(s): Congresses Notes: "Proceedings of the symposium on Ganglioside Structure, Function, and Biomedical Potential, held Julyat Parksville, Vancouver Island, British Columbia, Canada satellite to the ninth meeting of the.
Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence, and metabolism.
Key functional, biochemical, and pathobiochemical aspects are summarized. Ganglioside Structure and Function. Sphingolipids are building blocks of eukaryotic cell surfaces. They anchor lipid-bound carbohydrates to the plasma membrane and contribute to the epidermal water permeability barrier of the skin.
Glycolipid patterns can reach a high degree of complexity that constitutes a paradigm of combinatorial biosynthesis. GM2 is a type of ganglioside.
G refers to ganglioside, the M is for monosialic (as in it has one sialic acid), and 2 refers to the fact that it was the second monosialic ganglioside discovered. It is associated with GM2 gangliosidoses such as Tay–Sachs disease.
2 Additional images. 4 External links. Ganglioside GM2 activator Number:. Other articles where Ganglioside is discussed: lipid storage disease: disease, or amaurotic (blind) idiocy, gangliosides are deposited in body tissues, chiefly those of the central nervous system, which deteriorates, resulting in severe mental deficiency.
Characteristic early symptoms of Tay-Sachs disease include extreme sensitivity to noise, muscle weakness, and the appearance of a cherry.The NATO Advanced Research Workshop on "Gangliosides and Modu lation of Neuronal Functions" was held at the University of Stutt gart-Hohenheim, Federal Republic of Germany, on October 20 - 24, About 70 participants from 10 countries presented papers on a wide range of topics all concerning.Such antibodies have been injected into animals to generate models for studies of epilepsy and other neurological disorders.
References: 1. For classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, investigations.